Researchers from the Institute of Biotechnology (IBT) of the Autonomous University of Mexico (UNAM) conduct studies With Rana Cutaneous Secretions Endemic to the country, Pachymedusa Dacnicolor, to detect antimicrobial molecules that help control inflammations.
The specimen, a greenish range, is also known as the frog of a child, green frog or Mexican tree frog.
We focus on peptides with dual activity: antimicrobial and immunomodulator. We have several models, particularly for skin conditions such as psoriasis and atopic dermatitis, ”said Constance Auvynet in a statement issued by UNAM.
Auvynet together with Yvonne Rosenstein, both of the Molecular Medicine and Bioprocess Department of the IBT, pointed out that the objective of their investigations with the tree frog, which is particularly in the state of Morelos (center) and the coast of the state of Guerrero (south), “is Develop new safe treatmentseffective and accessible to combat inflammatory and infectious diseases. ”
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They also indicated that they have another model in elaboration against actinomicetone, which is a chronic granulomatous infection caused by various bacteria, the most frequent is Brazilian nocardia.
We purify small peptides with different functions. All are antimicrobial and many modulate the immune response, that is, they have a dual role, ”said Rosenstein. They currently conduct research at the biological level; the goal is that they can later move towards clinical studies.
They explained that peptides are produced by the glands of frog skin and can be collected by an electrical stimulus or by pressing their skin. In addition, they said that the procedure is possible to repeat it every 15 days, without the need to sacrifice the animal.
Rosenstein recalled that in all cultures natural products, plants and animals have been used, such as medicines sources or to alter behavior.
In your article ‘Ranas: from traditional medicine to new drugs’In the Biotechnology magazine in motion, the UNAM researchers explained that in mammals the peptides are in minimal quantities.
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In contrast, large proportions occur in the skin of amphibians, so it is possible to isolate enough material to obtain the amino acid sequence and test its pharmacological effects from a single specimen.
Added that throughout history in traditional medicine products have been used Obtained from frogsfor example for its recognized capacity to facilitate wound healing.
• The oldest reference dates back to the Assyrians (2000-1000 years AC) with the discovery of cuneiform writing tables in which the use of bile extracts of these animals mixed with milk is related to cure the infections of the eyes.
In Mexico, its use in traditional medicine since pre -Hispanic times is also documented. Some indigenous communities of the State of Mexico still use secretions of the TLALOC frog (Lithobates Tlaloci), endemic to the Mexico Basin, as a remedy for diabetes or cough.
(With EFE information)
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